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Beilstein J. Org. Chem. 2013, 9, 406–410, doi:10.3762/bjoc.9.42
Graphical Abstract
Figure 1: The neurotransmitter GABA.
Scheme 1: Synthesis of GABA-amide hydrochlorides 4a–c and 6a–f. (i) THF, reflux; (ii) MeOH, HCl (5%); (iii) T...
Figure 2: Effect of 7b on GABAA-receptor activation. (A) Superimposed traces of whole-cell currents induced b...
Figure 3: Absence of GABAA-receptor activation on application of 4c. Top traces: Examples of whole-cell curre...
Figure 4: Variation of EC50 values with the number n of methylene units separating the amide and the ammonium...
Figure 5: Effect of 7d on GABAA-receptor activation. (A,B) Superimposed traces of whole-cell currents induced...